Here is a paper A Mathematical Model for the Determination of Total Area Under Glucose Tolerance and Other Metabolic Curves, which has around 200 citations on Google Scholar. The objective of the paper is, according to the abstract, “To develop a mathematical model for the determination of total areas under curves from various metabolic studies.” The solution is actually simply the trapezoidal rule for numerical evaluation of the Riemann integral. The discussion is also quite interesting.

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## About Artem Novozhilov

I am an applied mathematician interested in studying various evolutionary processes by means of mathematical models. More on my professional activities can be found on my page
https://www.ndsu.edu/pubweb/~novozhil/